Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis.

@article{Zheng2011TolllikeR2,
  title={Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis.},
  author={Han Zheng and Mar{\'i}a C Dom{\'i}nguez Punaro and M. Garcia Segura and Claude Lachance and Serge Rivest and Jian-guo Xu and Mathieu Houde and Marcelo Gottschalk},
  journal={Journal of neuroimmunology},
  year={2011},
  volume={234 1-2},
  pages={71-83}
}
The murine astrocyte response to virulent Streptococcus suis, a swine and an emerging human meningitis-causing pathogen, is reported. Albeit astrocytes do not internalize S. suis, all S. suis strains studied enhanced Toll-like receptor (TLR)2 expression and the production of pro-inflammatory cytokines and inducible nitric oxide synthase. Cell wall components and hemolysin (suilysin) are shown to be mainly responsible for cell activation. Astrocytes from TLR2 knockout mice presented a partial… CONTINUE READING

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