Toll-like receptor 2 is important for the T(H)1 response to cutaneous sensitization.

@article{Jin2009TolllikeR2,
  title={Toll-like receptor 2 is important for the T(H)1 response to cutaneous sensitization.},
  author={Haoli Jin and Lalit Kumar and Clinton B Mathias and David Zurakowski and Hans C. Oettgen and Leonid Gorelik and Raif Geha},
  journal={The Journal of allergy and clinical immunology},
  year={2009},
  volume={123 4},
  pages={875-82.e1}
}
BACKGROUND Atopic dermatitis and allergic contact dermatitis are skin disorders triggered by epicutaneous sensitization with protein antigens and contact sensitization with haptens, respectively. Skin is colonized with bacteria, which are a source of Toll-like receptor (TLR) 2 ligands. OBJECTIVE We sought to examine the role of TLR2 in murine models of atopic dermatitis and allergic contact dermatitis. METHODS TLR2(-/-) mice and wild-type littermates were epicutaneously sensitized with… CONTINUE READING

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