Toll-like receptor 2-dependent extracellular signal-regulated kinase signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells.

@article{Richardson2015TolllikeR2,
  title={Toll-like receptor 2-dependent extracellular signal-regulated kinase signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells.},
  author={Edward T Richardson and Supriya Shukla and David R Sweet and Pamela A. Wearsch and Philip N Tsichlis and W Henry Boom and Clifford V Harding},
  journal={Infection and immunity},
  year={2015},
  volume={83 6},
  pages={2242-54}
}
Mycobacterium tuberculosis survives within macrophages and employs immune evasion mechanisms to persist in the host. Protective T helper type 1 (Th1) responses are induced, and the immune response in most individuals is sufficient to restrict M. tuberculosis to latent infection, but most infections are not completely resolved. As T cells and macrophages respond, a balance is established between protective Th1-associated and other proinflammatory cytokines, such as interleukin-12 (IL-12… CONTINUE READING
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