Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis

  title={Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis},
  author={Chantal A. Rivera and Latausha Gaskin and Monique Allman and Jia Hao Pang and Kristen Brady and Patrick A. Adegboyega and Kevin Pruitt},
  booktitle={BMC gastroenterology},
BACKGROUND Previously we reported that mice deficient in toll-like receptor 4 (TLR-4) signalling were protected from diet-induced non-alcoholic steatohepatitis (NASH). Another member of the toll-like receptor family, TLR-2, has been shown to play a role in lipid trafficking via uptake of diacylated lipoproteins. However, a role for TLR-2 in NASH has not been elucidated. The objectives of the current study were to examine the influence of dietary fat quality and TLR-2 on NASH pathogenesis… CONTINUE READING
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