Toll-like receptor 2 and Toll-like receptor 4 exhibit distinct regulation of cancer cell stemness mediated by cell death-induced high-mobility group box 1

@inproceedings{Chen2019TolllikeR2,
  title={Toll-like receptor 2 and Toll-like receptor 4 exhibit distinct regulation of cancer cell stemness mediated by cell death-induced high-mobility group box 1},
  author={Xuelian Chen and Fang Cheng and Yanfang Liu and Lirong Zhang and Lian Gong Song and Xiaojie Cai and Tao You and Xin Fan and Dongqing Wang and Aihua Gong and Haitao Zhu},
  booktitle={EBioMedicine},
  year={2019}
}
BACKGROUND High-mobility group box 1 (HMGB1), a common extracellular damage associated molecular pattern molecule, is overexpressed in several solid tumors including pancreatic carcinoma. We previously observed that radiotherapy induced dying cells secrete HMGB1 and accelerate pancreatic carcinoma progression through an unclear mechanism. METHODS Using the Millicell system as an in vitro co-culture model, we performed quantitative reverse transcriptase-polymerase chain reaction, western blot… CONTINUE READING
BETA

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 43 REFERENCES

Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis

  • Journal of experimental & clinical cancer research : CR
  • 2018
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Cancer stem cells revisited

  • Nature Medicine
  • 2017
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…