Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells.

@article{Ji2009TolllikeR2,
  title={Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells.},
  author={Suk Ji and Ji Eun Shin and Young Han Kim and Jaeho Oh and Byung-Moo Min and Youngnim Choi},
  journal={Infection and immunity},
  year={2009},
  volume={77 3},
  pages={
          1044-52
        }
}
We previously reported that infection by Fusobacterium nucleatum strongly induced the expression of both human beta-defensin 2 (HBD-2) and HBD-3 by gingival epithelial cells. The aim of this study was to characterize the pattern recognition receptors (PRRs) and regulatory mechanisms involved in the induction of HBD-2 and -3 expression by F. nucleatum in gingival epithelial cells. Immortalized human gingival epithelial HOK-16B cells were infected with live or heat-killed F. nucleatum, and the… CONTINUE READING

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