Toll-like receptor 2 and 4 expression after severe injury is not involved in the dysregulation of the innate immune system.

@article{Lendemans2007TolllikeR2,
  title={Toll-like receptor 2 and 4 expression after severe injury is not involved in the dysregulation of the innate immune system.},
  author={Sven Lendemans and Ernst Kreuzfelder and M Rita Hepsi Rani and Emilie Bayeeh and Fritz Ulrich Schade and Stefanie B. Floh{\'e} and Christian Waydhas and Sascha Floh{\'e}},
  journal={The Journal of trauma},
  year={2007},
  volume={63 4},
  pages={740-6}
}
BACKGROUND Severe injury after trauma is associated with a diminished production of different proinflammatory cytokines after stimulation with bacterial cell wall components. The cellular mechanisms, leading to a decreased responsiveness especially of monocytes after multiple injuries have not yet been elucidated in detail. The expression of Toll-like receptors (TLR) on leukocytes is essential for recognition of bacterial components. We investigated the expression of TLR2 and 4 in correlation… CONTINUE READING