Toll-like receptor 2 and 4 combination engagement upregulate IL-15 synergistically in human rheumatoid synovial fibroblasts.

@article{Jung2007TolllikeR2,
  title={Toll-like receptor 2 and 4 combination engagement upregulate IL-15 synergistically in human rheumatoid synovial fibroblasts.},
  author={Young-Ok Jung and Mi-La Cho and Chang-Min Kang and Jooyeon Jhun and Jong-Beom Park and Hye Jwa Oh and Jun-Ki Min and Sung-Hwan Park and Ho Youn Kim},
  journal={Immunology letters},
  year={2007},
  volume={109 1},
  pages={
          21-7
        }
}
Toll-like receptors (TLRs) are pattern-recognition receptors that connect innate and adaptive immunity. Interleukin-15 (IL-15) is a proinflammatory, innate response cytokine that mediates pleiotropic effector functions in inflammatory synovitis of rheumatoid arthritis (RA). The aim of this study was to clarify whether stimulation of TLR2 and TLR4 by their specific ligands induces the production of IL-15 in fibroblast-like synoviocytes (FLS) from RA patients. FLS were isolated from RA synovial… CONTINUE READING
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