Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans.

@article{Quesniaux2004TolllikeR2,
  title={Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans.},
  author={Val{\'e}rie F J Quesniaux and Delphine M M Nicolle and David Vilar Torres and Laurent Kremer and Yann Gu{\'e}rardel and J{\'e}r{\^o}me Nigou and Germain Puzo and François Erard and Bernhard Ryffel},
  journal={Journal of immunology},
  year={2004},
  volume={172 7},
  pages={4425-34}
}
Lipoarabinomannans (LAM) and lipomannans (LM) are integral parts of the mycobacterial cell wall recognized by cells involved in the innate immune response and have been found to modulate the cytokine response. Typically, mannosylated LAM from pathogenic mycobacteria have been reported to be anti-inflammatory, whereas phosphoinositol-substituted LAM from nonpathogenic species are proinflammatory molecules. In this study, we show that LM from several mycobacterial species, including Mycobacterium… CONTINUE READING
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