Toll-like receptor--a potent driving force behind rheumatoid arthritis.

  title={Toll-like receptor--a potent driving force behind rheumatoid arthritis.},
  author={Michiaki Takagi},
  journal={Journal of clinical and experimental hematopathology : JCEH},
  volume={51 2},
Toll like receptor (TLR), one of the key functions of innate immune system, can recognize not only exogenous pathogen-associated molecular patterns, namely PAMPs, but also endogenous molecules created upon tissue injury, sterile inflammation and degeneration. Endogenous TLR ligands are called as damage-associated molecular patters (DAMPs), including endogenous molecules released by activated and necrotic cells, and extracellular matrix molecules. DAMPs are also known as alarmins. TLR research… CONTINUE READING