Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria.

@article{Mockenhaupt2006TolllikeR,
  title={Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria.},
  author={Frank P Mockenhaupt and Jakob Peter Cramer and Lutz Hamann and Miriam S Stegemann and Jana Eckert and Na-Ri Oh and Rowland N Otchwemah and Ekkehardt Dietz and Stephan Ehrhardt and Nicolas W. J. Schr{\"o}der and Ulrich Bienzle and R. Randall Schumann},
  journal={The Journal of communicable diseases},
  year={2006},
  volume={38 3},
  pages={230-45}
}
Genetic host factors play a substantial role in susceptibility to and severity of malaria, which continues to cause at least one million deaths per year. Recently, members of the toll-like receptor (TLR) family have been shown to be involved in recognition of the etiologic organism Plasmodium falciparum: The glycosylphosphatidylinisitol anchor induces signaling in host cells via TLR-2 and -4, while hemozoin-induced immune activation involves TLR-9. Binding of microbial ligands to the respective… CONTINUE READING
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