Toll-like receptor (TLR) 2 and 4 mutations in periodontal disease.

  title={Toll-like receptor (TLR) 2 and 4 mutations in periodontal disease.},
  author={Matthias Folwaczny and J{\"u}rgen Glas and H-P T{\"o}r{\"o}k and Olga Limbersky and Christian Folwaczny},
  journal={Clinical and experimental immunology},
  volume={135 2},
Toll-like receptors (TLR) are signal molecules essential for the cellular response to bacterial cell wall components. Different functional effective polymorphisms for the TLR 4 gene (Asp299Gly; Thr399Ile) and for the TLR 2 gene (Arg677Trp, Arg753Gln) have recently been described that are associated with impaired lipopolysaccharide signal transduction. A total of 122 patients with chronic periodontal disease and 122 healthy unrelated controls were genotyped for the Asp299Gly and Thr399Ile… CONTINUE READING