Toll-like receptor (TLR)-2/4 expression in retinal ganglion cells in a high-glucose environment and its implications.

@article{Zhao2016TolllikeR,
  title={Toll-like receptor (TLR)-2/4 expression in retinal ganglion cells in a high-glucose environment and its implications.},
  author={Mingming Zhao and Chengli Li and Yu-ling Liu},
  journal={Genetics and molecular research : GMR},
  year={2016},
  volume={15 2}
}
Diabetic retinopathy (DR), a major complication of diabetes mellitus, is the leading cause of adult blindness. The Toll-like receptor (TLR) family is believed to be involved in the pathogenesis and progression of DR. Here, we investigated the expression profiles of TLR-2 and TLR-4 in retinal ganglion cells (RGCs), in an attempt to elucidate the role of these molecules in the etiology of DR. In vitro cultured RGCs were divided into control and high-glucose groups. The mRNA and protein levels of… CONTINUE READING