Toll-like Receptors as Sensors of Pathogens

  title={Toll-like Receptors as Sensors of Pathogens},
  author={Mikko Hallman and Mika R{\"a}met and R. Alan B. Ezekowitz},
  journal={Pediatric Research},
Initial recognition of microbes, as they enter the body, is based on germ line–encoded pattern recognition receptors that selectively bind to essential components of pathogens. This allows the body to respond immediately to the microbial invasion before the development of active immunity. The signal-transducing receptors that trigger the acute inflammatory cascade have been elusive until very recently. On the basis of their genetic similarity to the Toll signaling pathway in Drosophila… 

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