Toll-like Receptors Induce a Phagocytic Gene Program through p38

  title={Toll-like Receptors Induce a Phagocytic Gene Program through p38},
  author={Sean E. Doyle and Ryan M O'connell and Gustavo A. Miranda and Sagar A. Vaidya and Edward Kai-Hua Chow and Philip T Liu and Shinobu Suzuki and Nobutaka Suzuki and Robert L Modlin and Wen-chen Yeh and Timothy F. Lane and Genhong Cheng},
  journal={The Journal of Experimental Medicine},
  pages={81 - 90}
Toll-like receptor (TLR) signaling and phagocytosis are hallmarks of macrophage-mediated innate immune responses to bacterial infection. However, the relationship between these two processes is not well established. Our data indicate that TLR ligands specifically promote bacterial phagocytosis, in both murine and human cells, through induction of a phagocytic gene program. Importantly, TLR-induced phagocytosis of bacteria was found to be reliant on myeloid differentiation factor 88-dependent… CONTINUE READING
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