Toll-like Receptor (TLR) Signaling Interacts with CREBH to Modulate High-density Lipoprotein (HDL) in Response to Bacterial Endotoxin.

@article{Dandekar2016TolllikeR,
  title={Toll-like Receptor (TLR) Signaling Interacts with CREBH to Modulate High-density Lipoprotein (HDL) in Response to Bacterial Endotoxin.},
  author={Aditya Dandekar and Yining Qiu and Hyunbae Kim and Jiemei Wang and Xia Hou and Xuebao Zhang and Ze Jun Zheng and Roberto Mendez and Fu-Shin X Yu and Ashok Kumar and Deyu Fang and Fei Sun and Kezhong Zhang},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 44},
  pages={
          23149-23158
        }
}
Bacterial endotoxin can induce inflammatory and metabolic changes in the host. In this study, we revealed a molecular mechanism by which a stress-inducible, liver-enriched transcription factor, cAMP-responsive element-binding protein hepatic-specific (CREBH), modulates lipid profiles to protect the liver from injuries upon the bacterial endotoxin lipopolysaccharide (LPS). LPS challenge can activate CREBH in mouse liver tissues in a toll-like receptor (TLR)/MyD88-dependent manner. Upon LPS… CONTINUE READING