Toll-Like Receptors of Deuterostome Invertebrates

  title={Toll-Like Receptors of Deuterostome Invertebrates},
  author={Honoo Satake and Toshio Sekiguchi},
  booktitle={Front. Immun.},
Defensive systems against pathogens are responsible not only for survival or lifetime of an individual but also for the evolution of a species. Innate immunity is expected to be more important for invertebrates than mammals, given that adaptive immunity has not been acquired in the former. Toll-like receptors (TLRs) have been shown to play a crucial role in host defense of pathogenic microbes in innate immunity of mammals. Recent genome-wide analyses have suggested that TLR or their related… CONTINUE READING