Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation

  title={Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation},
  author={James Q Wang and Yogesh S Jeelall and Laura L. Ferguson and Keisuke Horikawa},
  booktitle={Front. Immunol.},
Pattern recognition receptors (PRRs) expressed on immune cells are crucial for the early detection of invading pathogens, in initiating early innate immune response and in orchestrating the adaptive immune response. PRRs are activated by specific pathogen-associated molecular patterns that are present in pathogenic microbes or nucleic acids of viruses or bacteria. However, inappropriate activation of these PRRs, such as the Toll-like receptors (TLRs), due to genetic lesions or chronic… CONTINUE READING


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