Toll-Like Receptor 4 Promoter Polymorphisms: Common TLR4 Variants May Protect against Severe Urinary Tract Infection

@inproceedings{Ragnarsdttir2010TollLikeR4,
  title={Toll-Like Receptor 4 Promoter Polymorphisms: Common TLR4 Variants May Protect against Severe Urinary Tract Infection},
  author={Brynd{\'i}s Ragnarsd{\'o}ttir and Klas Joensson and Alexander Urbano and Jenny Gr{\"o}nberg-Hern{\'a}ndez and Nataliya Lutay and Martti Tammi and Mattias Gustafsson and Ann-Charlotte Lundstedt and Irene Leijonhufvud and Diana Karpman and Bj{\"o}rn Wullt and Lennart Truedsson and Ulf Jodal and Bj{\"o}rn Andersson and Catharina Svanborg},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Polymorphisms affecting Toll-like receptor (TLR) structure appear to be rare, as would be expected due to their essential coordinator role in innate immunity. Here, we assess variation in TLR4 expression, rather than structure, as a mechanism to diversify innate immune responses. METHODOLOGY/PRINCIPAL FINDINGS We sequenced the TLR4 promoter (4,3 kb) in Swedish blood donors. Since TLR4 plays a vital role in susceptibility to urinary tract infection (UTI), promoter sequences were… CONTINUE READING
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