Toll-Like Receptor-4 Modulation for Cancer Immunotherapy

  title={Toll-Like Receptor-4 Modulation for Cancer Immunotherapy},
  author={Shanjana Awasthi},
  booktitle={Front. Immunol.},
INTRODUCTION Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition molecules. Since the discovery of the Toll pathway cascade (1, 2), our knowledge about the structure, function, and mechanics of TLRs in infectious and inflammatory conditions has increased remarkably. The role of TLR4 as a pathogenpattern recognition receptor has been studied extensively. We now know that TLR4 recognizes pathogen-associated molecular patterns (PAMPs), such as Gramnegative bacterial… CONTINUE READING
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