Toll-Like Receptor 3 Mediates a More Potent Antiviral Response Than Toll-Like Receptor 41

  title={Toll-Like Receptor 3 Mediates a More Potent Antiviral Response Than Toll-Like Receptor 41},
  author={Sean E. Doyle and Ryan M. O'Connell and Sagar A. Vaidya and Edward Kai‐Hua Chow and Kathleen M. Yee and Genhong Cheng},
  journal={The Journal of Immunology},
  pages={3565 - 3571}
We have recently described an IFN regulatory factor 3-mediated antiviral gene program that is induced by both Toll-like receptor (TLR)3 and TLR4 ligands. In our current study, we show that activation of IFN/viral response gene expression in primary macrophage cells is stronger and prolonged with TLR3 stimulation compared with that of TLR4. Our data also reveal that the cytoplasmic tails of both TLR3 and TLR4 can directly interact with myeloid differentiation factor 88 (MyD88). However, although… 

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