Toll-Like Receptor 2 Impairs Host Defense in Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis)

@article{Wiersinga2007TollLikeR2,
  title={Toll-Like Receptor 2 Impairs Host Defense in Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis)},
  author={W Joost Wiersinga and Catharina Wilhelmina Wieland and Mark C Dessing and Narisara Chantratita and Allen C Cheng and Direk Limmathurotsakul and Wirongrong Chierakul and Masja Leendertse and Sandrine Florquin and Alex F. de Vos and Nicholas J. White and Arjen Mattheus Dondorp and Nicholas P J Day and Sharon J Peacock and Tom van der Poll},
  journal={PLoS Medicine},
  year={2007},
  volume={4},
  pages={783 - 801}
}
BACKGROUND Toll-like receptors (TLRs) are essential in host defense against pathogens by virtue of their capacity to detect microbes and initiate the immune response. TLR2 is seen as the most important receptor for gram-positive bacteria, while TLR4 is regarded as the gram-negative TLR. Melioidosis is a severe infection caused by the gram-negative bacterium, Burkholderia pseudomallei, that is endemic in Southeast Asia. We aimed to characterize the expression and function of TLRs in septic… CONTINUE READING
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