Toll-Like Receptor 2 Deficiency Shifts PrP106-126-Induced Microglial Activation from a Neurotoxic to a Neuroprotective Phenotype

@article{Wang2014TollLikeR2,
  title={Toll-Like Receptor 2 Deficiency Shifts PrP106-126-Induced Microglial Activation from a Neurotoxic to a Neuroprotective Phenotype},
  author={Jihong Wang and Deming Zhao and Bo Pan and Yongyao Fu and Fushan Shi and Mohammed Kouadir and Lifeng Yang and Xiaomin Yin and Xiangmei Zhou},
  journal={Journal of Molecular Neuroscience},
  year={2014},
  volume={55},
  pages={880-890}
}
Prion diseases are fatal neurodegenerative diseases characterized by spongiform change, neuronal loss, and gliosis involving microglial activation in the central nervous system. Microglial activation is thought to play a key role in the pathogenesis of prion disease; however, the molecular mechanisms underlying prion-induced microglial activation are not… CONTINUE READING