Toll‐like receptor 2 has a prominent but nonessential role in innate immunity to Staphylococcus aureus pneumonia

@inproceedings{Skerrett2017TolllikeR2,
  title={Toll‐like receptor 2 has a prominent but nonessential role in innate immunity to Staphylococcus aureus pneumonia},
  author={Shawn J. Skerrett and Marissa H. Braff and H. Denny Liggitt and Craig E. Rubens},
  booktitle={Physiological reports},
  year={2017}
}
Staphylococcus aureus is an important cause of acute bacterial pneumonia. Toll-like receptor 2 (TLR2) recognizes multiple components of the bacterial cell wall and activates innate immune responses to gram-positive bacteria. We hypothesized that TLR2 would have an important role in pulmonary host defense against S. aureus TLR null (TLR2-/-) mice and wild type (WT) C57BL/6 controls were challenged with aerosolized S. aureus at a range of inocula for kinetic studies of cytokine and antimicrobial… CONTINUE READING
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