Tolfenamic acid interrupts the de novo synthesis of the β-amyloid precursor protein and lowers amyloid beta via a transcriptional pathway.

@article{Adwan2011TolfenamicAI,
  title={Tolfenamic acid interrupts the de novo synthesis of the β-amyloid precursor protein and lowers amyloid beta via a transcriptional pathway.},
  author={Lina I Adwan and Riyaz M. Basha and Maen Abdelrahim and Gehad Mohammed Subaiea and Nasser H. Zawia},
  journal={Current Alzheimer research},
  year={2011},
  volume={8 4},
  pages={385-92}
}
Amyloid beta (Aβ) peptides are related to the pathogenesis of Alzheimer's disease (AD). The search for therapeutic strategies that lower these peptides has mainly focused on the proteolytic processing of the β-amyloid precursor protein (APP), and other post-transcriptional pathways. The transcription factor specificity protein 1 (Sp1) is vital for the regulation of several genes involved in AD including APP and the beta site APP cleaving enzyme 1 (BACE1). We have previously reported that… CONTINUE READING
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