Tolerogenic dendritic cells impede priming of naïve CD8⁺ T cells and deplete memory CD8⁺ T cells.

  title={Tolerogenic dendritic cells impede priming of na{\"i}ve CD8⁺ T cells and deplete memory CD8⁺ T cells.},
  author={Fleur S. Kleijwegt and Diahann T S L Jansen and Josefine Teeler and Antoinette M. Joosten and Sandra Laban and Tatjana R. Nikolic and Bart O Roep},
  journal={European journal of immunology},
  volume={43 1},
Type 1 diabetes is a T-cell-mediated autoimmune disease in which autoreactive CD8(+) T cells destroy the insulin-producing pancreatic beta cells. Vitamin D3 and dexamethasone-modulated dendritic cells (Combi-DCs) loaded with islet antigens inducing islet-specific regulatory CD4(+) T cells may offer a tissue-specific intervention therapy. The effect of Combi-DCs on CD8(+) T cells, however, remains unknown. To investigate the interaction of CD8(+) T cells with Combi-DCs presenting epitopes on HLA… CONTINUE READING
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