Tolerogenic dendritic cells and their role in transplantation.

  title={Tolerogenic dendritic cells and their role in transplantation.},
  author={Mohamed B Ezzelarab and Angus W Thomson},
  journal={Seminars in immunology},
  volume={23 4},
The pursuit of clinical transplant tolerance has led to enhanced understanding of mechanisms underlying immune regulation, including the characterization of immune regulatory cells, in particular antigen-presenting cells (APC) and regulatory T cells (Treg), that may play key roles in promoting operational tolerance. Dendritic cells (DC) are highly efficient APC that have been studied extensively in rodents and humans, and more recently in non-human primates. Owing to their ability to regulate… CONTINUE READING