Tolerogenic dendritic cell vaccines to treat autoimmune diseases: can the unattainable dream turn into reality?

@article{Brussel2014TolerogenicDC,
  title={Tolerogenic dendritic cell vaccines to treat autoimmune diseases: can the unattainable dream turn into reality?},
  author={Ilse Van Brussel and Wai Ping Lee and Miche Rombouts and Amber H. Nuyts and Marthe Heylen and Benedicte Y De Winter and Nathalie Cools and Dorien M. Schrijvers},
  journal={Autoimmunity reviews},
  year={2014},
  volume={13 2},
  pages={138-50}
}
Autoimmune diseases affect about one in 15 individuals in developed countries and are characterized by a breakdown in immune tolerance. Current therapeutic approaches against destructive immune responses in autoimmune diseases are based on non-specific agents systemically suppressing the function of many immune effector cells. This indiscriminate immunosuppression, however, often causes serious and sometimes life-threatening side effects. Therefore, the need for more specific treatments… CONTINUE READING