Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage

  title={Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage},
  author={Priscila de Matos Silva and Julia Bier and Lisiery Negrini Paiatto and Cassia Galdino Albuquerque and Caique Lopes Souza and Lu{\'i}s Gustavo Romani Fernandes and Wirla Maria da Silva Cunha Tamashiro and Patricia Ucelli Simioni},
  booktitle={Journal of immunology research},
Dendritic cells (DCs), the most important professional antigen-presenting cells (APC), play crucial role in both immunity and tolerance. It is well known that DCs are able to mount immune responses against foreign antigens and simultaneously tolerate self-antigens. Since DCs can be modulated depending on the surrounding microenvironment, they can act as a bridge between innate and adaptive immunity. However, the mechanisms that support this dual role are not entirely clear. Recent studies have… CONTINUE READING
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