Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-gamma, interleukin-17, and antibody responses.

@article{Satpute2009TolerizationWH,
  title={Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-gamma, interleukin-17, and antibody responses.},
  author={Shailesh Ramchandra Satpute and Rajesh Rajaiah and Swamy Kumar Polumuri and Kamal D. Moudgil},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 1},
  pages={
          103-13
        }
}
OBJECTIVE Pretreatment of Lewis rats with soluble mycobacterial Hsp65 affords protection against subsequent adjuvant-induced arthritis (AIA). This study was aimed at unraveling the mechanisms underlying mycobacterial Hsp65-induced protection against arthritis, using contemporary parameters of immunity. METHODS Lewis rats were given 3 intraperitoneal injections of mycobacterial Hsp65 in solution prior to the initiation of AIA with heat-killed Mycobacterium tuberculosis. Thereafter… CONTINUE READING

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A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis.

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