Tolerance to the increased locomotor activity produced by l-5-hydroxytryptophan following peripheral decarboxylase inhibition in mice

@article{Magyar1978ToleranceTT,
  title={Tolerance to the increased locomotor activity produced by l-5-hydroxytryptophan following peripheral decarboxylase inhibition in mice},
  author={Regis L. Magyar and J. Christian Gillin and Richard Jed Wyatt},
  journal={Psychopharmacology},
  year={1978},
  volume={56},
  pages={343-350}
}
The development of tolerance to hyperactivity produced by l-5-hydroxytryptophan (5-HTP) was studied in mice pretreated with the peripheral decarboxylase inhibitor MK-486. The results of Experiment I indicated that partial tolerance developed to 5-HTP given twice daily (i.p.) at a dose of 400 mg/kg, but not at a dose of 800 mg/kg. Sustained hyperactivity at the greater dose (800 mg/kg) apparently resulted from the induction of seizures and stereotypy rather than increased locomotor activity… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 21 references

Some parallel findings in schizophrenic patients and serotonin-depleted cats

W. Dement, V. Zarcone, +4 authors J. Barchas
Schizophrenia: current concepts and research, • 1969
View 4 Excerpts
Highly Influenced

Effects of l-tryptophan on motor activity in mice

Psychopharmacologia • 1973
View 1 Excerpt

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