Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB‐oprM genes

@article{Pamp2008ToleranceTT,
  title={Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB‐oprM genes},
  author={S. J. Pamp and Morten Gjermansen and H. K. Johansen and T. Tolker‐Nielsen},
  journal={Molecular Microbiology},
  year={2008},
  volume={68}
}
  • S. J. Pamp, Morten Gjermansen, +1 author T. Tolker‐Nielsen
  • Published 2008
  • Biology, Medicine
  • Molecular Microbiology
  • Bacteria living as biofilm are frequently reported to exhibit inherent tolerance to antimicrobial compounds, and might therefore contribute to the persistence of infections. Antimicrobial peptides are attracting increasing interest as new potential antimicrobial therapeutics; however, little is known about potential mechanisms, which might contribute to resistance or tolerance development towards these compounds in biofilms. Here we provide evidence that a spatially distinct subpopulation of… CONTINUE READING
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