Tolerance to the anticonvulsant effect of morphine in mice: Blockage by ultra-low dose naltrexone
@article{Roshanpour2009ToleranceTT, title={Tolerance to the anticonvulsant effect of morphine in mice: Blockage by ultra-low dose naltrexone}, author={Maryam Roshanpour and M. Ghasemi and K. Riazi and Neda Rafiei-Tabatabaei and A. Dehpour}, journal={Epilepsy Research}, year={2009}, volume={83}, pages={261-264} }
SUMMARY
The present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a mouse model of clonic seizures induced by pentylenetetrazole, and whether ultra-low doses of the opioid receptor antagonist naltrexone which selectively block G(s) opioid receptors were capable of preventing the observed tolerance. The results showed that the morphine anticonvulsant effect could be subject to tolerance after repeated administration. Both the development and expression… CONTINUE READING
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References
SHOWING 1-10 OF 24 REFERENCES
Ultra-low dose naltrexone potentiates the anticonvulsant effect of low dose morphine on clonic seizures
- Medicine
- Neuroscience
- 2004
- 42
Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice
- Chemistry, Medicine
- Brain Research
- 1997
- 123
Convulsant and anticonvulsant effects of opioids: Relationship to GABA-mediated transmission
- Chemistry, Medicine
- Neuropharmacology
- 1982
- 49
The activity of opioid analgesics in seizure models utilizing N-methyl-dl-aspartic acid, kainic acid, bicuculline and pentylenetetrazole
- Medicine, Chemistry
- Neuropharmacology
- 1994
- 72
The role of nitric oxide in anticonvulsant and proconvulsant effects of morphine in mice
- Chemistry, Medicine
- Epilepsy Research
- 2002
- 93
Role of ATP-sensitive potassium channels in the biphasic effects of morphine on pentylenetetrazole-induced seizure threshold in mice
- Medicine
- Epilepsy Research
- 2007
- 41
Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment.
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1995
- 201
- PDF
Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions.
- Medicine
- Trends in pharmacological sciences
- 1998
- 157
Modulatory effects of Gs-coupled excitatory opioid receptor functions on opioid analgesia, tolerance, and dependence
- Chemistry, Medicine
- Neurochemical Research
- 2006
- 46
Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture
- Medicine
- Brain Research
- 1989
- 221
- PDF