Tolerance to the anticonvulsant effect of morphine in mice: Blockage by ultra-low dose naltrexone

@article{Roshanpour2009ToleranceTT,
  title={Tolerance to the anticonvulsant effect of morphine in mice: Blockage by ultra-low dose naltrexone},
  author={Maryam Roshanpour and Mehdi Ghasemi and Kiarash Riazi and Neda Rafiei-Tabatabaei and Mohammad Hossein Ghahremani and Ahmad Reza Dehpour},
  journal={Epilepsy Research},
  year={2009},
  volume={83},
  pages={261-264}
}
SUMMARY The present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a mouse model of clonic seizures induced by pentylenetetrazole, and whether ultra-low doses of the opioid receptor antagonist naltrexone which selectively block G(s) opioid receptors were capable of preventing the observed tolerance. The results showed that the morphine anticonvulsant effect could be subject to tolerance after repeated administration. Both the development and expression… 
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TLDR
It is demonstrated that anticonvulsant effect of morphine can be subject to tolerance after repeated administration, and a role for NMDA receptor/NO signaling in the development of tolerance to the anticonvalence of morphine is suggested.
Administration of lithium and magnesium chloride inhibited tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice
TLDR
It is demonstrated that the anticonvulsant effect of morphine is subject to tolerance after repeated administration, and both development and expression of tolerance are inhibited by either LiCl or MgCl(2).
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A role for KATP channels and the opioid system, alone or in combination, in the anticonvulsive effects of zolpidem is suggested.
Chemical composition of Zhumeria majdae essential oil and its effects on the expression of morphine withdrawal syndrome and tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice.
  • G. Azimi, J. Asgarpanah
  • Biology, Medicine
    Brazilian journal of biology = Revista brasleira de biologia
  • 2020
TLDR
The results suggest that ZMEO possesses constituent(s) that have activity against tolerance to the anticonvulsant effects of morphine and the morphine withdrawal symptoms.
INTERACTION OF MORPHINE WITH PROGESTERONE IN STRYCHNINE- INDUCED CONVULSION
TLDR
Reduced anticonvulsant effect of low dose progesterone by morphine seems to be a result of interaction of the morphine with neurotransmitters system such as GABAregic system.
Benzylidene Barbituric Acid Derivatives Shown Anticonvulsant Activity on Pentylenetetrazole-Induced Seizures in Mice: Involvement of Nitric Oxide Pathway
ABSTRACT Background: Barbituric acid derivatives have long been used as central nervous system (CNS) suppressants, such as sedatives, hypnotics and anticonvulsants. In addition, previous studies have
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