Tolerance to the anticonvulsant effect of morphine in mice: Blockage by ultra-low dose naltrexone

@article{Roshanpour2009ToleranceTT,
  title={Tolerance to the anticonvulsant effect of morphine in mice: Blockage by ultra-low dose naltrexone},
  author={Maryam Roshanpour and Mehdi Ghasemi and Kiarash Riazi and Neda Rafiei-Tabatabaei and Mohammad Hossein Ghahremani and Ahmad Reza Dehpour},
  journal={Epilepsy Research},
  year={2009},
  volume={83},
  pages={261-264}
}
SUMMARY The present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a mouse model of clonic seizures induced by pentylenetetrazole, and whether ultra-low doses of the opioid receptor antagonist naltrexone which selectively block G(s) opioid receptors were capable of preventing the observed tolerance. The results showed that the morphine anticonvulsant effect could be subject to tolerance after repeated administration. Both the development and expression… 
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Inhibition of NMDA receptor/NO signaling blocked tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice
TLDR
It is demonstrated that anticonvulsant effect of morphine can be subject to tolerance after repeated administration, and a role for NMDA receptor/NO signaling in the development of tolerance to the anticonvalence of morphine is suggested.
Administration of lithium and magnesium chloride inhibited tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice
TLDR
It is demonstrated that the anticonvulsant effect of morphine is subject to tolerance after repeated administration, and both development and expression of tolerance are inhibited by either LiCl or MgCl(2).
Interaction of morphine tolerance with pentylenetetrazole-induced seizure threshold in mice: The role of NMDA-receptor/NO pathway
TLDR
It is revealed that chronic treatment with morphine leads to the development of tolerance in mice, which in turn may cause an anticonvulsant effect in a high dose of morphine via the NMDA-R/NO pathway.
A role for opioid system in the proconvulsant effects of sildenafil on the pentylenetetrazole-induced clonic seizure in mice
TLDR
A role for opioidergic system in the proconvulsant effects of sildenafil on the PTZ-induced clonic seizures in mice is suggested.
VERAPAMIL INTERFERES WITH THE ANTICONVULSANT EFFECT OF MORPHIN IN A STRYECHNINE INDUCED CONVULSION MODEL IN MICE
TLDR
The reduced anticonvulsant effect of morphine by verapamil seems to be because of increase in morphine concentration in brain, which is mediated through different mechanisms.
Anticonvulsant Effects of Thalidomide on Pentylenetetrazole-Induced Seizure in Mice: A Role for Opioidergic and Nitrergic Transmissions
TLDR
The results indicate that opioidergic transmission and its interaction with neuronal NO signaling may contribute to the anti-seizure activity of thalidomide in the mice PTZ model of clonic seizure.
Involvement of ATP-sensitive potassium channels and the opioid system in the anticonvulsive effect of zolpidem in mice
TLDR
A role for KATP channels and the opioid system, alone or in combination, in the anticonvulsive effects of zolpidem is suggested.
Chemical composition of Zhumeria majdae essential oil and its effects on the expression of morphine withdrawal syndrome and tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice.
  • G. Azimi, J. Asgarpanah
  • Biology, Medicine
    Brazilian journal of biology = Revista brasleira de biologia
  • 2020
TLDR
The results suggest that ZMEO possesses constituent(s) that have activity against tolerance to the anticonvulsant effects of morphine and the morphine withdrawal symptoms.
INTERACTION OF MORPHINE WITH PROGESTERONE IN STRYCHNINE- INDUCED CONVULSION
TLDR
Reduced anticonvulsant effect of low dose progesterone by morphine seems to be a result of interaction of the morphine with neurotransmitters system such as GABAregic system.
Benzylidene Barbituric Acid Derivatives Shown Anticonvulsant Activity on Pentylenetetrazole-Induced Seizures in Mice: Involvement of Nitric Oxide Pathway
ABSTRACT Background: Barbituric acid derivatives have long been used as central nervous system (CNS) suppressants, such as sedatives, hypnotics and anticonvulsants. In addition, previous studies have…
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