Tolerance to the anticonvulsant effect of morphine in mice: Blockage by ultra-low dose naltrexone

@article{Roshanpour2009ToleranceTT,
  title={Tolerance to the anticonvulsant effect of morphine in mice: Blockage by ultra-low dose naltrexone},
  author={Maryam Roshanpour and M. Ghasemi and K. Riazi and Neda Rafiei-Tabatabaei and A. Dehpour},
  journal={Epilepsy Research},
  year={2009},
  volume={83},
  pages={261-264}
}
  • Maryam Roshanpour, M. Ghasemi, +2 authors A. Dehpour
  • Published 2009
  • Medicine
  • Epilepsy Research
  • SUMMARY The present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a mouse model of clonic seizures induced by pentylenetetrazole, and whether ultra-low doses of the opioid receptor antagonist naltrexone which selectively block G(s) opioid receptors were capable of preventing the observed tolerance. The results showed that the morphine anticonvulsant effect could be subject to tolerance after repeated administration. Both the development and expression… CONTINUE READING
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