Tolerance to the anticonvulsant effect of morphine in mice: Blockage by ultra-low dose naltrexone

@article{Roshanpour2009ToleranceTT,
  title={Tolerance to the anticonvulsant effect of morphine in mice: Blockage by ultra-low dose naltrexone},
  author={Maryam Roshanpour and Mehdi Ghasemi and Kiarash Riazi and Neda Rafiei-Tabatabaei and Mohammad Hossein Ghahremani and Ahmad Reza Dehpour},
  journal={Epilepsy Research},
  year={2009},
  volume={83},
  pages={261-264}
}

VERAPAMIL INTERFERES WITH THE ANTICONVULSANT EFFECT OF MORPHIN IN A STRYECHNINE INDUCED CONVULSION MODEL IN MICE

The reduced anticonvulsant effect of morphine by verapamil seems to be because of increase in morphine concentration in brain, which is mediated through different mechanisms.

Anticonvulsant Effect of Minocycline on Pentylenetetrazole-Induced Seizure in Mice: Involvement of 5-HT3 Receptor.

Investigation of the anticonvulsant effect of acute administration of minocycline on pentylenetetrazole (PTZ)-induced seizures revealed that this effect is mediated, at least in part, by inhibition of 5-HT3 receptor.

Chemical composition of Zhumeria majdae essential oil and its effects on the expression of morphine withdrawal syndrome and tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice.

The results suggest that ZMEO possesses constituent(s) that have activity against tolerance to the anticonvulsant effects of morphine and the morphine withdrawal symptoms.

INTERACTION OF MORPHINE WITH PROGESTERONE IN STRYCHNINE- INDUCED CONVULSION

Reduced anticonvulsant effect of low dose progesterone by morphine seems to be a result of interaction of the morphine with neurotransmitters system such as GABAregic system.

The opioid antagonist naltrexone decreases seizure‐like activity in genetic and chemically induced epilepsy models

Using zebrafish larvae as an initial model system, it is found that the opioid antagonist naltrexone exhibited an anticonvulsant effect and this effect was validated in three other epilepsy models and presented as a promising anticonVulsive candidate.

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Cotreatment of mice with morphine plus ultra-low-dose NTX does, in fact, enhance the antinociceptive potency of morphine in tail-flick assays and attenuate development of withdrawal symptoms in chronic, as well as acute, physical dependence assays.

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Summary:  Purpose: To evaluate the effect of the α2‐adrenoceptor agonist clonidine and the antagonist yohimbine on the dual modulation of seizure susceptibility induced by morphine and the