Tolerance to the anticonvulsant effect of morphine in mice: Blockage by ultra-low dose naltrexone

@article{Roshanpour2009ToleranceTT,
  title={Tolerance to the anticonvulsant effect of morphine in mice: Blockage by ultra-low dose naltrexone},
  author={Maryam Roshanpour and Mehdi Ghasemi and Kiarash Riazi and Neda Rafiei-Tabatabaei and Mohammad Hossein Ghahremani and Ahmad Reza Dehpour},
  journal={Epilepsy Research},
  year={2009},
  volume={83},
  pages={261-264}
}
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27 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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27 Citations

Inhibition of NMDA receptor/NO signaling blocked tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice

Administration of lithium and magnesium chloride inhibited tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice

A role for opioid system in the proconvulsant effects of sildenafil on the pentylenetetrazole-induced clonic seizure in mice

VERAPAMIL INTERFERES WITH THE ANTICONVULSANT EFFECT OF MORPHIN IN A STRYECHNINE INDUCED CONVULSION MODEL IN MICE

The reduced anticonvulsant effect of morphine by verapamil seems to be because of increase in morphine concentration in brain, which is mediated through different mechanisms.

Anticonvulsant Effect of Minocycline on Pentylenetetrazole-Induced Seizure in Mice: Involvement of 5-HT3 Receptor.

Investigation of the anticonvulsant effect of acute administration of minocycline on pentylenetetrazole (PTZ)-induced seizures revealed that this effect is mediated, at least in part, by inhibition of 5-HT3 receptor.

Involvement of ATP-sensitive potassium channels and the opioid system in the anticonvulsive effect of zolpidem in mice

Chemical composition of Zhumeria majdae essential oil and its effects on the expression of morphine withdrawal syndrome and tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice.

The results suggest that ZMEO possesses constituent(s) that have activity against tolerance to the anticonvulsant effects of morphine and the morphine withdrawal symptoms.

INTERACTION OF MORPHINE WITH PROGESTERONE IN STRYCHNINE- INDUCED CONVULSION

Reduced anticonvulsant effect of low dose progesterone by morphine seems to be a result of interaction of the morphine with neurotransmitters system such as GABAregic system.

Seizure susceptibility alteration through 5-HT3 receptor: Modulation by nitric oxide

The opioid antagonist naltrexone decreases seizure‐like activity in genetic and chemically induced epilepsy models

Using zebrafish larvae as an initial model system, it is found that the opioid antagonist naltrexone exhibited an anticonvulsant effect and this effect was validated in three other epilepsy models and presented as a promising anticonVulsive candidate.

References

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Ultra-low dose naltrexone potentiates the anticonvulsant effect of low dose morphine on clonic seizures

Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice

Convulsant and anticonvulsant effects of opioids: Relationship to GABA-mediated transmission

The activity of opioid analgesics in seizure models utilizing N-methyl-dl-aspartic acid, kainic acid, bicuculline and pentylenetetrazole

The role of nitric oxide in anticonvulsant and proconvulsant effects of morphine in mice

Role of ATP-sensitive potassium channels in the biphasic effects of morphine on pentylenetetrazole-induced seizure threshold in mice

Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment.

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Cotreatment of mice with morphine plus ultra-low-dose NTX does, in fact, enhance the antinociceptive potency of morphine in tail-flick assays and attenuate development of withdrawal symptoms in chronic, as well as acute, physical dependence assays.

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The Role of α2‐Adrenoceptors in the Modulatory Effects of Morphine on Seizure Susceptibility in Mice

Summary:  Purpose: To evaluate the effect of the α2‐adrenoceptor agonist clonidine and the antagonist yohimbine on the dual modulation of seizure susceptibility induced by morphine and the…