Tolerance to self-administration of cocaine in rats: time course and dose-response determination using a multi-dose method.

@article{EmmettOglesby1993ToleranceTS,
  title={Tolerance to self-administration of cocaine in rats: time course and dose-response determination using a multi-dose method.},
  author={M. W. Emmett-Oglesby and R{\'e}gis Peltier and R. Y. Depoortere and Cynthia Pickering and Matthew Hooper and Yebin Gong and John Douglas Lane},
  journal={Drug and alcohol dependence},
  year={1993},
  volume={32 3},
  pages={247-56}
}
To assess tolerance to cocaine in a self-administration paradigm, rats were trained to self-administer cocaine (0.25 mg/injection) on a fixed-ratio 2 (FR2) schedule of reinforcement. The development of tolerance was studied during chronic administration of cocaine (20 mg/kg per 8 h for 10 days), given either contingently (self-administered by the rats) or non-contingently (infused by the experimenter). Both contingent and non-contingent administration of cocaine produced comparable tolerance… CONTINUE READING