Tolerance to repeated nicotine administration on performance, subjective, and physiological responses in nonsmokers

@article{Heishman2000ToleranceTR,
  title={Tolerance to repeated nicotine administration on performance, subjective, and physiological responses in nonsmokers},
  author={Stephen J. Heishman and Jack E. Henningfield},
  journal={Psychopharmacology},
  year={2000},
  volume={152},
  pages={321-333}
}
Rationale: When administered acutely to nonsmokers, nicotine's effects on performance are inconsistent, perhaps because of suboptimal dosing or initial dysphoria that could interfere with performance. Objective: The purpose of this study was to determine if a range of nicotine doses administered for 8 days to nonsmokers would enhance psychomotor and cognitive abilities and to document the development of nicotine tolerance or sensitization. Methods: Twelve male volunteers, who reported ever… CONTINUE READING

7 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Nicotine produced dose - related increases in ratings of dysphoria and negative mood , including tension , anxiety , nervousness , turning of stomach , and sedation .
Nicotine produced dose - related increases in ratings of dysphoria and negative mood , including tension , anxiety , nervousness , turning of stomach , and sedation .
All Topics