Tolerance to repeated microinjection of morphine into the periaqueductal gray is associated with changes in the behavior of off- and on-cells in the rostral ventromedial medulla of rats.

Abstract

Although the administration of opioids is the most effective treatment for pain, their efficacy is limited by the development of tolerance. The midbrain periaqueductal gray matter (PAG) participates in opioid analgesia and tolerance. Microinjection of morphine into PAG produces antinociception, probably through neurons in the rostral ventromedial medulla… (More)

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@article{Tortorici2001ToleranceTR, title={Tolerance to repeated microinjection of morphine into the periaqueductal gray is associated with changes in the behavior of off- and on-cells in the rostral ventromedial medulla of rats.}, author={V{\'i}ctor Tortorici and Michael M. Morgan and Horacio Vanegas}, journal={Pain}, year={2001}, volume={89 2-3}, pages={237-44} }