Tolerance to non-opioid analgesics in PAG involves unresponsiveness of medullary pain-modulating neurons in male rats.

@article{Tortorici2009ToleranceTN,
  title={Tolerance to non-opioid analgesics in PAG involves unresponsiveness of medullary pain-modulating neurons in male rats.},
  author={V{\'i}ctor Tortorici and Yexica Aponte and Humberto P. Acevedo and Lourdes M. Nogueira and Susan Vanessa Hern{\'a}ndez Vanegas},
  journal={The European journal of neuroscience},
  year={2009},
  volume={29 6},
  pages={
          1188-96
        }
}
Opiate analgesia can be hampered by a reduction in pharmacological effectiveness (tolerance), and this crucially depends on the periaqueductal gray matter (PAG). Non-opioids like metamizol (dipyrone) or aspirin also induce PAG-dependent analgesia and tolerance, but the neuronal bases of this tolerance are unknown. Metamizol is a pyrazolon derivative and cyclooxygenase inhibitor with widespread use as an analgesic in Europe and Latin America. Metamizol was microinjected into the PAG of awake… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES

The periaqueductal gray as critical site for antinociception and tolerance induced by non-steroidal anti-inflammatory drugs

  • H. Vanegas, V. Tortorici
  • Research Signpost, Kerala,
  • 2007
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…