Tolerance to nicotine's effects in the elevated plus-maze and increased anxiety during withdrawal

@article{Irvine2001ToleranceTN,
  title={Tolerance to nicotine's effects in the elevated plus-maze and increased anxiety during withdrawal},
  author={Elaine E Irvine and Survjit Cheeta and Sandra E. File},
  journal={Pharmacology Biochemistry and Behavior},
  year={2001},
  volume={68},
  pages={319-325}
}
In the elevated plus-maze test of anxiety, nicotine (0.1 mg/kg sc; 30 min after injection) had a significant anxiogenic effect, shown by specific decreases in the percentage of time spent on the open arms and in the percentage of open-arm entries. Tolerance developed to this anxiogenic effect after 7 days of nicotine treatment (0.1 mg/kg/day). Five minutes after an acute injection, nicotine (0.1 mg/kg) was ineffective, but after 7 days of treatment a significant anxiolytic effect, shown by… CONTINUE READING

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