Tolerance to multiple doses of the pulmonary toxicant, naphthalene.

  title={Tolerance to multiple doses of the pulmonary toxicant, naphthalene.},
  author={Kathryn A O'Brien and C Suverkropp and Sarathchandra Kanekal and Charles G. Plopper and Alan R. Buckpitt},
  journal={Toxicology and applied pharmacology},
  volume={99 3},
Intraperitoneal administration of single doses of the volatile aromatic hydrocarbon, naphthalene, resulted in dose-dependent bronchiolar epithelial cell necrosis in mice. Twenty-four hours after a dose of 50 mg/kg, swelling of Clara cells with some exfoliation of epithelial cells was evident in half of the treated animals. At doses of 100 mg/kg small numbers of necrotic and swollen cells with pyknotic nuclei were observed. At 200 mg/kg there were substantial numbers of bronchiolar epithelial… CONTINUE READING


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