Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.

@article{ZieglerHeitbrock1994ToleranceTL,
  title={Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.},
  author={H W Loms Ziegler-Heitbrock and Angela Wedel and Winfried W Schraut and Martin Stroebel and P Wendelgass and Thomas Sternsdorf and P Atricka . Baeuerle and Jane Glenn Haas and Gert Prof Dr Riethmueller},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 25},
  pages={
          17001-4
        }
}
Stimulation of the human monocytic cell line Mono Mac 6 with lipopolysaccharide (LPS) leads to rapid and transient expression of cytokines like tumor necrosis factor (TNF). When such cells are precultured for 2 days with a low dose of LPS (20 ng/ml) followed by stimulation with a high dose of LPS (1 microgram/ml), expression of the TNF gene is minimal, i.e. the cells are tolerant. In nuclear run-on analysis, such tolerant cells show only a low degree of transcription, indicating that tolerance… CONTINUE READING

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