Tolerance to ethanol intoxication after chronic ethanol: role of GluN2A and PSD-95.

Abstract

The neural and genetic factors underlying chronic tolerance to alcohol are currently unclear. The GluN2A N-methyl-D-aspartate receptors (NMDAR) subunit and the NMDAR-anchoring protein PSD-95 mediate acute alcohol intoxication and represent putative mechanisms mediating tolerance. We found that chronic intermittent ethanol exposure (CIE) did not produce… (More)
DOI: 10.1111/adb.12110

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