Tolerance to ethanol hypothermia in inbred mice: genotypic correlations with behavioral responses.

@article{Crabbe1982ToleranceTE,
  title={Tolerance to ethanol hypothermia in inbred mice: genotypic correlations with behavioral responses.},
  author={J Christopher F Crabbe and Jeri S. Janowsky and Emmett R. Young and Ann E. K. Kosobud and Jeffrey M. Stack and Henk Rigter},
  journal={Alcoholism, clinical and experimental research},
  year={1982},
  volume={6 4},
  pages={446-58}
}
Hypothermia was studied 5 min before, and 30 and 60 min after intraperitoneal administration of ethanol (3 g/kg) in 20 inbred strains of mice. Ethanol was given daily for 8 days, and temperatures were taken on Days 1, 3, 5, and 8. Tolerance was indexed by the reduction in hypothermia over days. There were large strain differences in baseline temperature, the hypothermic effect of ethanol, and in development of tolerance to hypothermia. Some strains of mice (DBA/1J, DBA/2N, MA/MyJ, and PL/J) did… CONTINUE READING