Tolerance to daytime sedative effects of H1 antihistamines.

  title={Tolerance to daytime sedative effects of H1 antihistamines.},
  author={Gary S. Richardson and Timothy A. Roehrs and L P M Rosenthal and Gail Koshorek and Thomas Roth},
  journal={Journal of clinical psychopharmacology},
  volume={22 5},
Sedation is the principal side effect of first generation H1 antihistamines, and recent studies have suggested that this side effect should limit the clinical application of these drugs. The sedative effect also underlies the use of these first-generation drugs as nonprescriptive remedies for insomnia. In both cases, the potential for tolerance to the sedative effect of these drugs is an important issue for which there are few objective data. In the study reported here, 15 healthy men age 18 to… CONTINUE READING
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