Tolerance to cocaine in brain stimulation reward following continuous cocaine infusions

@article{Pudiak2014ToleranceTC,
  title={Tolerance to cocaine in brain stimulation reward following continuous cocaine infusions},
  author={C. Pudiak and R. Kuolee and M. Bozarth},
  journal={Pharmacology Biochemistry and Behavior},
  year={2014},
  volume={122},
  pages={246-252}
}
This study examined tolerance to cocaine's threshold-lowering effect in brain stimulation reward (BSR) following continuous cocaine infusions and secondly, used the nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester (L-NAME) to determine NO's involvement in the development of cocaine tolerance. Animals were continuously infused with saline or cocaine (30 mg/kg per day) via osmotic minipump for 14 days and injected daily with saline or L-NAME (30 mg/kg, i.p.) following BSR testing… Expand
1 Citations

References

SHOWING 1-10 OF 75 REFERENCES
Cocaine disposition in the brain after continuous or intermittent treatment and locomotor stimulation in mice.
Behavioral and neurochemical effects of continuous infusion of cocaine in rats
L-NAME and MK-801 attenuate sensitization to the locomotor-stimulating effect of cocaine.
Intermittent and Continuous cocaine Administration: Residual Behavioral states during withdrawal
Cocaine euphoria, dysphoria, and tolerance assessed using drug-induced changes in brain-stimulation reward
Postcocaine depression and sensitization of brain-stimulation reward: Analysis of reinforcement and performance effects
Inhibition of nitric oxide synthase in the ventral tegmental area attenuates cocaine sensitization in rats
Low dose cocaine self‐administration transiently increases but high dose cocaine persistently decreases brain reward function in rats
...
1
2
3
4
5
...