• DOI:10.1016/j.pbb.2014.04.006
Corpus ID: 207332822

Tolerance to cocaine in brain stimulation reward following continuous cocaine infusions

@article{Pudiak2014ToleranceTC,
  title={Tolerance to cocaine in brain stimulation reward following continuous cocaine infusions},
  author={C. Pudiak and R. Kuolee and M. Bozarth},
  journal={Pharmacology Biochemistry and Behavior},
  year={2014},
  volume={122},
  pages={246-252}
}

• C. Pudiak, R. Kuolee, M. Bozarth
• Published 2014
• Medicine
• Pharmacology Biochemistry and Behavior

This study examined tolerance to cocaine's threshold-lowering effect in brain stimulation reward (BSR) following continuous cocaine infusions and secondly, used the nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester (L-NAME) to determine NO's involvement in the development of cocaine tolerance. Animals were continuously infused with saline or cocaine (30 mg/kg per day) via osmotic minipump for 14 days and injected daily with saline or L-NAME (30 mg/kg, i.p.) following BSR testing… Expand