Tolerance to changes in membrane lipid composition as a selected trait of membrane proteins.

@article{Sanders2011ToleranceTC,
  title={Tolerance to changes in membrane lipid composition as a selected trait of membrane proteins.},
  author={Charles R Sanders and Kathleen F. Mittendorf},
  journal={Biochemistry},
  year={2011},
  volume={50 37},
  pages={
          7858-67
        }
}
Membrane lipid composition can vary dramatically across the three domains of life and even within single organisms. Here we review evidence that the lipid-exposed surfaces of membrane proteins have generally evolved to maintain correct structure and function in the face of major changes in lipid composition. Such tolerance has allowed evolution to extensively remodel membrane lipid compositions during the emergence of new species without having to extensively remodel the associated membrane… CONTINUE READING
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