Tolerance to antinociceptive effects of morphine without tolerance to its effects on schedule-controlled behavior


The development of tolerance to behavioral effects of morphine was investigated in rats that responded on a two-lever, multiple-trial, multiple differential-reinforcement-of-low-rate fixed-ratio (mult DRL FR) schedule of food presentation. Stable performances were maintained when sessions were conducted just twice per week. The effects of cumulative doses… (More)
DOI: 10.1007/BF00210839


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