Tolerance to amino acid variations in peptides binding to the major histocompatibility complex class I protein H-2Kb.

@article{Udaka1995ToleranceTA,
  title={Tolerance to amino acid variations in peptides binding to the major histocompatibility complex class I protein H-2Kb.},
  author={Keiko Udaka and K H Wiesm{\"u}ller and Stefan Kienle and Guenther Jung and Peter Walden},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 41},
  pages={24130-4}
}
Major histocompatibility complex (MHC) class I molecules are cell-surface glycoproteins that bind peptides and present them to T cells. The formation of a peptide-MHC complex is the initial step in specific, T cell-mediated immune responses. But, unlike other receptor-ligand systems, peptides are essential for a stable conformation of the MHC proteins. To investigate the contribution of every amino acid of octapeptides to the stability and antigenic integrity of MHC proteins, complex… CONTINUE READING