Tolerance to Nitrous Oxide Analgesia in Rats and Mice

@article{Berkowitz1979ToleranceTN,
  title={Tolerance to Nitrous Oxide Analgesia in Rats and Mice},
  author={Barry A. Berkowitz and A. Donald Finck and Martin D. Hynes and Shih Hsun Ngai},
  journal={Anesthesiology},
  year={1979},
  volume={51},
  pages={309–312}
}
The purpose of these experiments was to characterize the nature of tolerance to the analgesic action of nitrous oxide. Analgesia was assessed in rats using a tail-flick latency test and in mice using an abdominal constriction test. Rats and mice were exposed to nitrous oxide, 75 per cent, the balance oxygen, continuously for 16–18 hours. On re-exposure to nitrous oxide 30 min later, these animals were found tolerant to nitrous oxide in that the analgesic response was decreased by at least 50… Expand
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