Tolerance to Nitrous Oxide Analgesia in Rats and Mice

  title={Tolerance to Nitrous Oxide Analgesia in Rats and Mice},
  author={Barry A. Berkowitz and A. Donald Finck and Martin D. Hynes and Shih Hsun Ngai},
The purpose of these experiments was to characterize the nature of tolerance to the analgesic action of nitrous oxide. Analgesia was assessed in rats using a tail-flick latency test and in mice using an abdominal constriction test. Rats and mice were exposed to nitrous oxide, 75 per cent, the balance oxygen, continuously for 16–18 hours. On re-exposure to nitrous oxide 30 min later, these animals were found tolerant to nitrous oxide in that the analgesic response was decreased by at least 50… Expand
Nitrous Oxide-Induced Hypothermia in the Rat Acute and Chronic Tolerance
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A study of analgesic and dependence producing actions of nitrous oxide in mice.
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Influence of Chronic Ethanol Exposure on Nitrous Oxide Analgesia in Mice
Findings suggest the possibility that subjects with a history of alcohol abuse might have reduced responsiveness to nitrous oxide in a clinical setting. Expand
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It is indicated that rats below 3 wk old lack an antinociceptive effect to nitrous oxide by using the tail flick test, which is consistent with the fact that the descending noradrenergic neurons, which are required for the analgesic action of N(2)O, are not anatomically or functionally developed at birth and take more than three weeks to fully develop in rats. Expand
Enkephalinase Inhibition Prevented Tolerance to Nitrous Oxide Analgesia in Rats
The results indicate that tolerance to N2O analgesia can be abolished by activation of the enkephalinergic system, which might suggest a possible insufficiency of this system during tolerance toN2O. Expand
Influence of narcotic antagonist drugs upon nitrous oxide analgesia in mice
The findings suggest that nitrous oxide analgesia might involve an activation of kappa-opioid receptors in the central nervous system; however, a possible involvement of mu-opIOid receptors is not absolutely precluded by this study. Expand
Nitrous oxide-induced hypothermia in the rat.
It is suspected that N2O-induced hypothermia in rats is possibly not mediated by opiate receptors, and its selective antagonism by naloxone (but not naltrexone) may be due to a unique non-opioid analeptic action of nalxone. Expand
Antagonism of nitrous oxide antinociception in mice by intrathecally administered antisera to endogenous opioid peptides.
The hypothesis that nitrous oxide antinociception in the mouse abdominal constriction test involves the neuronal release of DYN and ME in the spinal cord is supported. Expand
Antagonism of Nitrous Oxide Antinociception in Mice by Intrathecally Administered Antisera to Endogenous Opioid Peptides
Previously it was demonstrated that nitrous oxide antinociception in the mouse abdominal constriction test is mediated by κ-opioid receptors. Since nitrous oxide is thought to cause the neuronalExpand