Tolerance of spironolactone

  title={Tolerance of spironolactone},
  author={Bronwyn R. Hughes and William James Cunliffe},
  journal={British Journal of Dermatology},
A survey of 54 patients taking spironolactone for hirsutes or acne showed that side‐effects occurred in 91%; in 80% of patients, these were related to the anti‐androgenic mechanism of the drug (menstrual disturbances, and breast enlargement and tenderness). The concomitant use of a contraceptive pill gave a lower incidence of menstrual abnormalities. Only seven patients (13%) had to stop the drug. In a further eight patients, a reduction in dose to between 125 and 175 mg daily achieved a… Expand
Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial.
The present data obtained in a randomized prospective study clearly demonstrate that the pure antiandrogen flutamide is superior to spironolactone in the treatment of female hirsutism and its related androgen-dependent symptoms and signs in women. Expand
Efficacy and tolerance of acne treatment using both spironolactone and a combined contraceptive containing drospirenone.
The combination of EE/DRSP and SL 100 mg daily appears to have efficacy and is well tolerated in the treatment of severe papular and nodulocystic acne in women. Expand
Antiandrogen and hormonal treatment of acne.
The drugs discussed in this article include spironolactone, cyproterone acetate, flutamide, oral contraceptives, corticosteroids, finasteride, and gonadotropin-releasing hormone agonists. Expand
Predictors of clinical response in hirsute women treated with spironolactone.
Low-dose spironolactone improves hirsutism in a majority of hirsute women, irrespective of age, severity or duration of hirutism, menstrual status, or serum hormone levels. Expand
Long-Term Safety of Spironolactone in Acne: Results of an 8-Year Followup Study
The long-term use of spironolactone in the treatment of acne in women appears to be safe, although side effects are common, although not usually a cause for stopping the drug. Expand
Effects and side‐effects of spironolactone therapy in women with acne
An open‐labelled, prospective study to evaluate the effects and side‐effects of spironolactone therapy in women with acne. Expand
Spironolactone is an effective and well tolerated systemic antiandrogen therapy for Hirsute women.
It is concluded that spironolactone is effective and well tolerated for hirsute women and caused objective changes in hair growth. Expand
Antiandrogens: Clinical Aspects
For a long time, the only means for combatting hirsutism were ablative surgery, the mechanical removal of body hair such as through shaving, plucking, waxing, chemical depilation and electrolysis, orExpand
Antiandrogens and acne. A topical approach?
A new topical antiandrogen, inocoterone acetate (RU882) has recently been evaluated for the treatment of acne, and this new development is discussed in the overall context of anti androgen therapy. Expand
Facial contact dermatitis due to spironolactone in an anti‐acne cream
Systemic spironolactone has been successfully prescribed in patients affected by androgen-related disorders such as acne vulgaris, hirsutism and androgenic alopecia and is proposed as a new therapeutic approach for both men and women. Expand


Oral spironolactone improves acne vulgaris and reduces sebum excretion
The clinical response was dose‐dependent, with maximum subjective and objective benefit when spironolactone doses of 150–200 mg were used, but there was no correlation between sebum response and androgen status. Expand
Oral spironolactone: an effective treatment for acne vulgaris in women
Initial plasma androgen levels were no higher in responders than in non‐responders, nor did oral contraceptive use appear to affect clinical response, and spironolactone is a useful alternative therapy for women with acne vulgaris. Expand
Treatment of hirsutism with spironolactone.
  • R. Tremblay
  • Medicine
  • Clinics in endocrinology and metabolism
  • 1986
It is concluded that spironolactone is an effective drug in the treatment of female hirsutism on the basis of the data and the clinical experience. Expand
10 Treatment of hirsutism with spironolactone
Spironolactone is an effective drug in the treatment of female hirsutism and good to very good clinical results were observed in patients who were under study for a minimum of 3 to 4 years. Expand
Treatment of hirsutism with spironolactone.
Spironolactone is a highly effective and safe agent for the treatment of hirsutism through its inhibitory action on both ovarian androgen secretion and peripheral androgen action. Expand
Spironolactone in combination drug therapy for unresponsive hirsutism.
The study suggests that combination drug therapy is an efficacious and well-tolerated approach to the management of unresponsive hirsutism. Expand
Antiandrogenic effect of spirolactones: mechanism of action.
It seems likely that spirolactones, besides their action on testosterone biosynthesis, exert their antiandrogenic activity via a peripheral androgen antagonism. Expand
Effect of spironolactone on the sexual differentiation of rat foetuses
  • Treatment of hirsutism with spironolactone . ^ / ^ m Med Assoc
  • 1982
Treatment of hirsutism with spironolactone.^/^m
  • Med Assoc
  • 1982
Anti - androgenic effect of spironolactones : mechanism of action
  • Endocrinology
  • 1975