Tolerance of peripheral nerve to intraoperative radiotherapy (IORT): clinical and experimental studies.

@article{Kinsella1985ToleranceOP,
  title={Tolerance of peripheral nerve to intraoperative radiotherapy (IORT): clinical and experimental studies.},
  author={Timothy J. Kinsella and William F Sindelar and A M Deluca and G H Pezeshkpour and Russell L. Smith and Michael Maher and R O Terrill and Robert Miller and Arnold Mixon and J F Harwell},
  journal={International journal of radiation oncology, biology, physics},
  year={1985},
  volume={11 9},
  pages={1579-85}
}
In our clinical experience combining wide excision and intraoperative radiotherapy (IORT), five patients have developed clinical signs of lumbosacral or sciatic neuropathy within 9 months of receiving IORT to a dose of 20-25 Gy. Three patients showed recovery of nerve function over several months while two patients have shown no recovery and have near complete loss of extremity function. In an attempt to investigate this clinical observation further, the lumbosacral plexus and sciatic nerve of… CONTINUE READING